In 2009, “Science Magazine” published a newly released paper from Whittemore Peterson Institute about the existence of XMRV, (which stands for xenotropic murine leukemia virus related virus,) which looked to be a causative agent in CFS, Fibromyalgia, Prostate Cancer and several other neuro-immune disorders.

The race was on.

All around the world there were doors opened for research scientists to apply this remarkable discovery and try to find better diagnostic tools, better treatment and of course – the great career maker – finding a cure.

Somehow, I am willing to bet that the excitement surrounding the original research had more to do with the potential impact on prostate cancer patients.

Why?

Well, if you aren’t familiar with “Osler’s Web: Inside The Labyrinth of the Chronic Fatigue Syndrome Epidemic”, then perhaps you are unaware of the government scandal that was exposed by author Hillary Johnson in 1996 proving fraud to the tune of many millions of dollars that had been earmarked from Congress to the CDC to research CFS/ME, but had been applied to other programs.  This involved cooked books and lying to Congress amongst many other crimes by an entire division at CDC.

Thankfully those funds have been accounted for and new programs put together under new management at the CDC.

So, up until the announcement last year by WPI, there had been very few breakthroughs regarding cause or cure, and the XMRV discovery gave the estimated 17  millions of sufferers hope for the first time in many years.

Now, a year later, the mud slinging has begun with small studies that seem designed to do nothing more than cast doubt on the original work at WPI.  With the close connections that have been drawn between CFS/ME, Fibromyalgia, RA, MS, Autism, chronic Lyme disease (Oooh, yes we have been told by the dark robed priests of the IDSA that there is no such thing as chronic Lyme disease!) by top researchers who have been written about elsewhere in this blog, one must question the validity of the mud-slingers, and wonder if continued funding will allow WPI and other reputable research firms to solve the mystery of XMRV – amazingly only the third type of virus known to mankind at this time.

So little is known just yet, but enough for some medical doctors who are themselves infected with chronic Lyme to consider jumping ship altogether and dividing Lyme sufferers into those who respond to antibiotics – those without XMRV, and those who don’t respond to antibiotics, don’t have Lyme and have XMRV instead which would explain quite a bit about the vast differences between treatment responses.

One such doctor is Jamie Deckoff-Jones, MD who tells her story convincingly at http://treatingxmrv.blogspot.com/2010/05/thoughts-about-chronic-lyme-disease.html

It has been so exciting to think that perhaps XMRV would give chronic Lyme, CFS/ME, Fibromyalgia and other chronic illnesses some hope for future help.  But it appears that the baby may be getting thrown out with the bath water.

Out of the tragic and deadly AIDS epidemic; medical researchers have brought about a wave of new scientific breakthroughs which has benefited hundreds if not thousands of suffering people with related diseases due to immune dysfunction.

As the search for better tools and treatments continue to advance for “AIDS”, there have been more and more infections that have come to light with startling similarities and frightening correlations – most recently a retrovirus present in Chronic Fatigue Immune Dysfunction Syndrome (CFIDS) and prostate cancer.

The October issue of Science Magazine reports that researchers from the Whittemore Peterson Institute (WPI), located at the University of Nevada, Reno, the National Cancer Institute (NCI), (part of the National Institutes of Health) have discovered a retroviral link to “CFIDS”, a debilitating disease that affects millions of people in the United States.

Given the close relationship between those who suffer with chronic neurological Lyme disease, MS, Fibromyalgia,  and CFS, it is not surprising to see similarities in the mutual findings of Dr. Judy Mikovits (pictured at top of story), the brilliant biochemist and respected scientific researcher for WPI (Institute from Neuro-Immune Disease) and recent leader of the team that discovered this association.

“We now have evidence that a retrovirus named XMRV is frequently present in the blood of patients with CFS. This discovery could be a major step in the discovery of vital treatment options for millions of patients,” said Dr. Mikovits in a recent press release.

The WPI team provide a new hypothesis for a retrovirus link with CFS. The virus, XMRV, was first identified by Robert H. Silverman, Ph.D., professor in the Department of Cancer Biology at the Cleveland Clinic Lerner Research Institute, in men who had a specific immune system defect that reduced their ability to fight viral infections.

“The discovery of XMRV in two major diseases, prostate cancer and now chronic fatigue syndrome, is very exciting. If cause-and-effect is established, there would be a new opportunity for prevention and treatment of these diseases,” said Silverman, a co-author on the CFS paper.

These results were also supported by the observation of retrovirus particles in patient samples when examined using transmission electron microscopy. The data demonstrate the first direct isolation of infectious XMRV from humans.

“These compelling data allow the development of a hypothesis concerning a cause of this complex and misunderstood disease, since retroviruses are a known cause of neurodegenerative diseases and cancer in man,” said Francis Ruscetti, Ph.D., Laboratory of Experimental Immunology, NCI.

Retroviruses like XMRV have also been shown to activate a number of other latent viruses. This could explain why so many different viruses, such as Epstein-Barr virus, which was causally linked to Burkitt’s and other lymphomas in the 1970s, have been associated with CFS. It is important to note that retroviruses, like XMRV, are not airborne.

“The scientific evidence that a retrovirus is implicated in CFS opens a new world of possibilities for so many people,” said Annette Whittemore, founder and president of WPI and mother of a CFS patient. “Scientists can now begin the important work of translating this discovery into medical care for individuals with XMRV related diseases.”

Dan Peterson, M.D., medical director of WPI added, “Patients with CFS deal with a myriad of health issues as their quality of life declines. I’m excited about the possibility of providing patients, who are positive for XMRV, a definitive diagnosis, and hopefully very soon, a range of effective treatments options.”

Researchers cautioned however, that this finding shows there is an association between XMRV and CFS but does not prove that XMRV causes CFS. However, the WPI has such confidence in their findings that they have actually renamed CFS “XAND” for X Associated Neuro=Immune Disease.

WPI further states:

We have detected the retroviral infection XMRV is greater than 95% of the more than 200 ME/CFS, Fibromylagia, Atypical MS patients tested. The current working hypothesis is that XMRV infection of B, T, NK and other cells of the innate immune response causes the chronic inflammation and immune deficiency resulting in an inability to mount an effective immune response to opportunistic infections.

This discovery opens an entire new avenue of Neuro-Immune Disease related research and our discovery has brought to this field world-renown immunologists and retrovirologists building our team of collaborators to translate our discoveries into new treatments as soon as possible.

Because retroviruses are known to cause inflammatory diseases, neurological disease immune deficiency and cancer the discovery of XMRV has far reaching implications for the prevention and treatment of not only lymphoma, one of the potentially devastating complications of ME/CFS but prostate cancer and perhaps many others such as neurological Lyme disease.

The Whittemore Peterson Institute for Neuro Immune Disease exists to bring discovery, knowledge, and effective treatments to patients with illnesses that are caused by acquired dysregulation of both the immune system and the nervous system, often resulting in lifelong disease and disability.